Blog

Credibly reintermediate backend ideas for cross-platform models. Continually reintermediate integrated processes through technically sound intellectual capital.
Evento-Dar-2021-1200x798.jpg

The meeting was held on December 9 and brought together the experiences of international donors and the expectations of potential donors to the Colombian program (DarCélulas).

Diciembre, 2021. DarCélulas is a research project executed by the District Institute of Science, Biotechnology and Innovation in Health (IDCBIS) with funding from the Science, Technology and Innovation Fund of the General System of Royalties and the District Administration of Bogota.

The purpose of the project is to create the first large database of blood-forming cell donors (also called stem cells), a registry of people willing to save the lives of people who do not know and have diseases such as leukemia.

Registries today exist in many countries around the world such as Japan and the United States; and in Latin America in Mexico, Argentina and Chile, among others. While in Colombia, the creation of the first registry was given in 2019 and with it, the realization of an annual event in which the updated information of the program is shared to the community of registered donors.

The first loyalty event was face-to-face at the Konrad Lorenz University in 2019, where the first balance and perspectives were presented. The 2020 event was virtual and was held with the slogan "compatible with life", in this version it was reported that the program would open its doors to other cities, in addition to Bogota, and experiences of international records were shown.

In the 2021 version, held on December 9, the protagonists were the potential donors who have registered in Colombia, who were the guests of honor at the event; on the other hand, an international story of a donor and a patient who were connected through a donation and were able to meet each other was shown. In addition, the expectations of potential donors who have registered in Bogota, Medellin, Cali and Barranquilla were made known.

At present, the program has surpassed the 3,000 people registered and more than 15,000 pre-registered.

Watch here #EventoDar2021:


investigadores-del-idcbis-presentan-trabajo-cientifico-en-ingenieria-tisular-en-el-congreso-mundial-1200x600.png

7 September, 2020 CellsNews
Dr. Ingrid Silva, PhD and Luz Stella Correa, PhD, Master Candidate in Genetics, are attending the TERMIS Society World Congress, which is being held in the city of Kyoto, Japan from September 4 to 7 of this year. The World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) is the most important scientific event in the field of Tissue Engineering since it brings together researchers, academic and industry sectors, world leaders in the development of advanced therapies oriented to tissue regeneration.

investigadores-del-idcbis-reciben-reconocimiento-por-descubrir.jpeg

7 September, 2020 CellsInvestigation

Considering that stem cell transplantation for blood diseases depends on several factors including the patient, the disease, the compatibility and the source of stem cells used, it is important to investigate the factors of the collection, isolation, freezing and thawing process to which these cells are subjected.

For the success of a stem cell transplant it is necessary firstly to have compatibility between donor and recipient, secondly it is necessary that the cells are sufficient according to the patient's weight and that they are in good condition after thawing (living stem cells).

The IDCBIS Public Cord Blood Bank with a scientific approach has been analyzing different variables that may allow improving the processes or identifying characteristics of the cord blood units that allow predicting the success of the transplant.

The umbilical cord blood units collected from altruistic donors in the district are processed in the bank until they are frozen for storage, performing analysis on tissue compatibility molecules, among other analyses.

The finding was awarded by the scientific committee of 16th International Cord Blood Symposium was that removing red blood cells from cord blood units could improve the quality of stem cells for transplantation.

The committee also considered very novel the finding that certain genetic variants present in donors predispose to a better or worse quality of cord blood units, which would allow to choose them before transplantation and avoid transplant failures.

These results were presented by IDCBIS researchers, Dr. Ana María Perdomo Arciniegas and Dr. Diana Vanegas, who represented the Bank's group of researchers, presented the research and resolved the concerns of the most important scientists in the area.


celulas-mesenquimales-1200x600.jpg

13 April, 2020 Cells

Researchers from the Advanced Therapies Unit of IDCBIS advance in the research on the biology of mesenchymal cells and their possible applications in medicine, with the aim of improving the quality of life of patients with different conditions.

Why are these cells causing interest in the medical world?

Mesenchymal cells are actively involved in the repair and regeneration of some tissues such as bone, cartilage and skin. These cells can multiply artificially in a suitable environment and specialize according to the stimuli they receive to achieve their reparative effect.Mesenquimalv4

Impressive, isn't it? And these cells are in your body right now.

In IDCBIS laboratories, scientists investigate the properties of mesenchymal cells in controlled environments. There are still many questions to be answered about mesenchymal cells, so our team of researchers is studying them, modifying them, controlling them and developing technologies that will allow them to be used in the future as drugs to improve the lives of patients.

One of their characteristics is that they are immunomodulatory cells.

 

The capacity of these cells to regulate the immune system has been scientifically proven, and when activated in excess, it can affect a person's health.

La artritis reumatoide es una enfermedad en la cual nuestro propio sistema inmunitario ataca diferentes estructuras y tejidos del cuerpo, produciendo dolor e inflamación crónica. A partir de la investigación que se adelanta en la Unidad de Terapias Avanzadas del IDCBIS se busca aprovechar la capacidad de regulación inmunológica de estas células, buscando en un futuro próximo poder aplicarlas en pacientes con esta enfermedad, en especial en aquellas personas que no responden a las terapias convencionales disponibles.

Their possible use in the treatment of some autoimmune diseases such as RA, systemic lupus erythematosus or multiple sclerosis, among others, illustrates the potential of these cells (which we will talk much more about in future articles).

In other words

These cells multiply and grow, they also develop and specialize. While some generate bone tissue, others can produce muscle or cartilage tissue. We can compare their development to that of a community of people where individuals multiply and grow, but specialize in a function to contribute to the community, while some become engineers, others become sociologists or doctors, etc.

Did you know that there are cells that specialize in creating our blood? You can learn more about them at www.idcbis.org.co/darcelulas.

Our objective with this article is to let you know some important facts about the research that is taking place today in the city of Bogota with this type of cells. There are many more interesting characteristics and details about mesenchymal cells and in general about the technological advances that make possible the development of products based on cells with medicinal properties.

Below you can see what the mesenchymal cells look like. Photograph taken in our laboratory, where they are observed with fibroblastoid shape adherent to the plastic of the culture flask.

IMG Microscopio

If you liked this content and would like to know more, we will gladly listen to your comments through our social networks. Follow us on Facebook, Twitter, Instagram, Youtube y LinkedIn as @IDCBIS


mas-de-750-personas-han-dicho-si-a-la-posibilidad-de-donar-celulas-1200x600.jpg

14 August, 2019 CellsInvestigationNews

7 out of 10 patients who need a blood-forming cell transplant (bone marrow) do not find a compatible donor in their family, therefore it is necessary to look for this compatibility in unrelated people. Genetic similarity is necessary for the procedure to be successful.

The District Institute of Science, Biotechnology and Innovation in Health IDCBIS, linked to the Health Sector of the Capital District, is carrying out a database of potential donors who could save the lives of patients with diseases such as leukemia, among other serious blood diseases. 

The only way to find a compatible, non-family donor is to have previously identified the genetic characteristics of a population and store them in a database, so that the patient's medical team can search for a possible donor. This database is called the National Registry of Hematopoietic Progenitor Cell Donors.

This type of initiative is already being carried out in other countries such as Japan, New Zealand, the United States and more. In Latin America it has been carried out in Mexico, Argentina, Brazil, Chile and Uruguay. For the first time Colombia will have a donor registry.

Since January 21, 2019, the DarCélulas program began, in which the processes of pre-registration and registration to the Registry were organized, as well as the communication to invite people interested in becoming potential donors in this first stage, subsequently when there is an optimal number of donors, the specialists who attend patients who require a transplant will be able to consult the Registry.  

You may be interested in: First 20 transplants with umbilical cord blood cells donated by Colombian mothers to IDCBIS's Public Cord Blood Bank

In the online pre-registration stage, through the web page www.idcbis.org.co, Colombians can find out much more about the process, as well as schedule an appointment for registration, then to formalize the registration the interested party attends in person at the IDCBIS District Blood Bank where blood samples will be taken to know their genetic information and to register it in the database that is being built. For now the registration process is only available in Bogota.

The resulting database in all registries at international level is available for searches, therefore there have already been successful cases of transplantation in Colombia, thanks to donors registered in other countries. This initiative in our country would give us the possibility of having Colombian donors, with a greater possibility of being compatible with patients in the same territory, since there is a greater possibility of having similar genetic characteristics.

*On August 22nd at 11:00 a.m. the presenter and journalist, Carlos Calero who is a brand ambassador for DarCélulas will attend the IDCBIS District Blood Bank to register for the program and explain to the public the importance of donating blood-forming cells. 


equipo-de-investigacion-del-banco-publico-de-sangre-de-cordon.png

The investigation team of the Public Cord Blood Bank IDCBIS reveals frequencies of genes of the population of Bogota donors important in the compatibility in transplants of blood-forming cells, this was done through the study titled HLA -A, -B, -C, -DRB1 and –DQB1 allele and haplotype frequencies of 1463 umbilical cord blood units typed in high resolution from Bogotá, Colombia, which will appear in the important scientific journal Human Immunology member of the American Society of Histocompatibility and Immunogenetics.

Dr. Ana María Perdomo led the research team that carried out the study through which the frequencies of the HLA (Human Leukocyte Antigen) genetic variants of 1463 umbilical cord blood units stored for unrelated transplantation (without family relationship) were calculated. This means a representative sample of the HLA genes of Colombian children, which is immunologically determinant for the eventual transplantation of umbilical cord blood units.

With the statistical data presented in the study, possible associations between the different HLA variants can be inferred, which is useful for blood-forming cell donor registries in the world, to predict possible compatibilities with patients who have similar genotypes, including the possibility of finding a donor in our country. When there is compatibility between donors and patients, rejection at the time of receiving a transplant is avoided.

First Colombian population study typed with five DNA characteristics

Through the collection of more than 9,300 cord blood units since 2014, with 1666 made available for transplantation by the IDCBIS Public Cord Blood Bank, it has been possible to identify the HLAs corresponding to the 1463 units.

Typing is the process through which HLA identification is made, which was performed on each umbilical cord blood unit. This is the first study that takes into account five DNA characteristics in the Colombian population in order to obtain relevant information for transplants.

You may be interested in: Delegation of researchers from Lazio - Italy visits IDCBIS in search of international cooperation

The study published in the scientific journal Human Immunology allows an approach to the most frequent variants in the genes present in the HLA in the Colombian population. "Knowing more about the genetic characteristics in high resolution of our population, we can contribute to donor search strategies, as well as make transplant processes increase their chances of success in patients who require it," says Dr. Ana Maria Perdomo, IDCBIS researcher.

The Public Cord Blood Bank IDCBIS, linked to the Health Sector of the Capital District, is in charge of selecting donors, as well as collecting, processing, analyzing, storing, typing and distributing umbilical cord blood units, which are used for the treatment of different diseases that affect the blood, immune system, metabolism or bone marrow, especially in underage patients.


Read the article here


25 January, 2019 CellsNews0

The IDCBIS presents the call for financial support for the development of a master's degree related to the donation of hematopoietic progenitor cells, since one of our functions is to manage lines of research and technological innovation in various fields of human health sciences, with emphasis on transfusion medicine, tissue engineering, advanced therapy and regenerative medicine in coordination with national and international academic and research centers.

Invitation here

In accordance with the above, we attach the call and ratify the dates of the process set forth therein.

If you have any questions, please contact the Innovation and Organizational Development Group:

PBX 3649620 ext. 9468

Stage Dates
Publication of the terms of the call for proposals January 10, 2019
Registration of application documents February 28, 2019
Verification of compliance with minimum requirements March 4, 2019
Evaluation of proposals and interviews and final selection March 5 to 15, 2019
Notification of results March 18, 2019

idcbis-participo-en-el-iii-curso-internacional-de-trasplante-de-celulas-03-1200x900.jpg

8 December, 2017 Cells0

The IDCBIS Cord Blood Bank team, led by Dr. Ana María Perdomo, participated on October 19, 20 and 21 in the III International Course on Hematopoietic Progenitor Cell Transplantation organized by the Colombian Association of Hematology and Oncology. The course was held at the Intercontinental Hotel in the city of Cali, Valle del Cauca.

During the second day, Dr. Perdomo presented to the hematology and oncology specialists the experience in HSC transplants with units from the Colombian public Cord Blood Bank.


Learn more about the Cord Blood Bank



Logo a color IDCBIS Centro de investigación reconocido por minciencias r-1763-2021

PASIÓN POR LA CIENCIA Y LA VIDA



en_USEnglish
Skip to content