Investigación - Instituto Distrital de Ciencia, Biotecnología e Innovación en Salud

The District Institute of Science, Biotechnology and Innovation in Health - IDCBIS, was elected for the fourth consecutive year by the Council as the deserving recipient of the Order of Social Responsibility Donate Bogota in the category that recognizes individuals and associations that have worked or made efforts to encourage and promote the culture of organ and tissue donation for transplantation and implantation purposes in the capital.

This award recognized the work carried out by IDCBIS through its District Tissue Bank, the only multipurpose bank in the country and the first in Latin America with development and standardization in acellular dermis to favor the regeneration of definitive skin in burned patients. The Bank has INVIMA certification in GMP for ocular tissue, skin and amniotic membrane, and is also a Latin American reference in donor selection, rescue, processing, storage and distribution of human tissues for implant purposes.

Dr. Bernardo Camacho, Director of IDCBIS, thanked the honorable Council of Bogota for this award, but especially praised the families of deceased donors and those who generously and altruistically gave their authorization in life to give another chance of life to patients who have required an organ or tissue transplant. He also invited the general population to join the culture of donation, which has been so affected by the pandemic.

In what circumstances is tissue donated?

Organs and tissues can be obtained from living or deceased donors.
In the case of living donors, appropriate conditions must be guaranteed to minimize as much as possible the risks assumed by the person who wishes to voluntarily donate tissue, following the legal and medical requirements already established.
In terms of tissues, corneas, skin, bones, bone marrow, blood vessels, heart valves, cartilage, tendons, sclera and amniotic membrane can be transplanted.

The District Tissue Bank IDCBIS (District Institute of Science, Biotechnology and Innovation in Health) in collaboration with the Advanced Therapies Unit is leading a research project that could help people who have suffered severe alterations in their corneas to recover, especially if they have suffered burns or severe allergies, such as Steven-Johnson syndrome.

The research line is in its first phase and its main objective is to advance in the culture of limbal cells, a type of cell capable of self-renewing and regenerating the corneal epithelium.

Mauricio Latorre, medical director of ocular tissue at the IDCBIS District Tissue Bank, states that any person who has deficiencies at the corneal limbus level could benefit from this treatment and, if proven effective, the patient would not have to rely on amniotic membrane grafts or chemical medications to counteract his condition and could instead have access to direct cell recovery that would prevent further deterioration.

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Currently, an alternative for people with adverse conditions in the corneas is transplantation, a solution that despite the cultural change that has been seen in Colombia in recent years in terms of tissue donation, is still limited in part by the proliferation of myths, this accentuated with the pandemic that forced medical personnel to increase the selection criteria for potential donors and extreme epidemiological measures and tests to ensure the biosafety of each of the potential tissues for transplantation.

Dr. Latorre explained that although the research is at an early stage, the results obtained so far are promising.

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Continuing with the exercise of the continuous search for international scientific cooperation and thus strengthen knowledge networks with experts in different areas of knowledge, we have received the delegation of the mission of Lazio - Italy in Bogota, who learned firsthand the research capabilities and projects led by IDCBIS.

These initiatives are possible because the IDCBIS is registered as a flagship project of Bogota and is part of the Biopolo area of the Smart Specialization Strategy of the Bogota Chamber of Commerce.

The Smart Specialization of the Bogota Region is an integrated agenda for productive development built collectively for the transformation of Bogota and Cundinamarca based on knowledge and innovation. A dynamic strategy that responds to regional capabilities and international trends for the generation of projects.

Five areas were prioritized for its implementation, made up of a set of productive activities, some of them consolidated and others barely emerging: Bogota Creative Region, Bio-pole, Business Services, Advanced Knowledge HUB and Sustainable City Region.

The IDCBIS is part of the group called Bio-pole, which refers to the development of life sciences, including technologies and productive activities pertaining to agriculture and agro-industry, fine chemistry and health.

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Considering that stem cell transplantation for blood diseases depends on several factors including the patient, the disease, the compatibility and the source of stem cells used, it is important to investigate the factors of the collection, isolation, freezing and thawing process to which these cells are subjected.

For the success of a stem cell transplant it is necessary firstly to have compatibility between donor and recipient, secondly it is necessary that the cells are sufficient according to the patient's weight and that they are in good condition after thawing (living stem cells).

The IDCBIS Public Cord Blood Bank with a scientific approach has been analyzing different variables that may allow improving the processes or identifying characteristics of the cord blood units that allow predicting the success of the transplant.

The umbilical cord blood units collected from altruistic donors in the district are processed in the bank until they are frozen for storage, performing analysis on tissue compatibility molecules, among other analyses.

The finding was awarded by the scientific committee of 16^th International Cord Blood Symposium was that removing red blood cells from cord blood units could improve the quality of stem cells for transplantation.

The committee also considered very novel the finding that certain genetic variants present in donors predispose to a better or worse quality of cord blood units, which would allow to choose them before transplantation and avoid transplant failures.

These results were presented by IDCBIS researchers, Dr. Ana María Perdomo Arciniegas and Dr. Diana Vanegas, who represented the Bank's group of researchers, presented the research and resolved the concerns of the most important scientists in the area.

Donate blood when it is needed most

On October 30, the District Blood Bank IDCBIS started a new blood donation program called Inagotables. This program seeks to respond to the need to collect blood components, which increases in the middle and end of the year.

The mission is to find committed blood donors, since they would be the ones who, with their donations, would become a hope for the patients at the moment when they need it the most.

The idea was born from the District Blood Bank IDCBIS because, with the experience of more than 17 years supplying the needs of blood components in the network of public hospitals in the District, it is known how much the reduction in blood donations during the holiday season can affect patients.

Considering that it is recommended to donate blood every 6 months, it is expected that the Inagotables will donate blood twice a year. This would occur right at the time of greatest need.

It is expected, with the consolidation of this altruistic community, to contribute to the knowledge of the culture of donation and combat the myths that exist around blood donation with some messages that will be transmitted in the digital media of the District Institute of Science, Biotechnology and Innovation in Health, IDCBIS.

The registration process consists of entering www.idcbis.org.co/inagotables, the goal is to get more information and fill out a questionnaire, so that the person who completes the process is committed to donate blood on the date of greatest need. Whoever completes this process could be scheduled for the next blood donation day.

The team of collaborators of the District Blood Bank IDCBIS continues its daily work of approaching different communities to fulfill the mission of getting blood components to patients in need of transfusion. So if someone wants to make their blood donation immediately, you can consult the days at https://idcbis.org.co/banco-distrital-de-sangre/

From 2017 date of creation of the District Institute of Science Biotechnology and Innovation in Health, IDCBIS, linked to the Health Sector of the Capital District, six publications have been made in indexed journals. Each one has been developed based on the lines of research in advanced therapies, regenerative medicine and transfusion medicine.

The efforts of IDCBIS researchers have resulted in the generation of impact knowledge, since the indexed journals are high quality research publications that are listed in databases that can be consulted worldwide.

IDCBIS is currently a national and international reference in its fields of performance. A very important part of the Institute's progress is due to the research conducted by the GIMTTyC group, recently categorized as Group A by Colciencias.

Before becoming the IDCBIS, the institution was recognized as a District Hemocenter, and research in transfusion medicine was carried out. Since then, research progress has become more and more frequent at the Institute, using the curiosity to generate new knowledge based on experience as a driving force. These processes have been achieved thanks to the collaboration of researchers with high degrees of specialization in their areas.

You may be interested in: Research team of the Public Cord Blood Bank IDCBIS makes important publication in the scientific journal Human Immunogoly

The following is a tour of published research that has resulted in a breakthrough in treatment for patients in need of skin or blood-forming cell transplants.

1 Gamma ray skin preservation study

In this study, Dr. Bernardo Camacho, director of the Institute, and Dr. Linda Guerrero, director of the IDCBIS Skin Bank, conducted a study in which gamma ray irradiation is tested on skin used in transplants.

This work was developed comparing irradiated and non-irradiated transplanted skin with observation of the results. As a conclusion it was found that skin irradiated with gamma rays contributes to close wounds with higher quality and safety when transplanted.

2 Increased chances of cord blood cell transplantation through a new collection strategy.

Donated units of cord blood forming cells can be used in transplantation to help patients with severe blood diseases, for this reason they are collected in the Public Cord Blood Bank. Not all units can be used as some do not meet the required number of nucleated cells.

In this investigation, developed by the team of the Public Cord Blood Bank, procurement methods were tested with which a greater amount of nucleated cells can be obtained for each unit, giving each donation a greater chance of becoming a possible transplant.

3 Improved procedure for thawing umbilical cord blood units

Cord blood cells are frozen at -196 degrees Celsius for preservation. In the thawing process prior to transplantation, there is a risk of significant cell loss. In the development of this study, a method is described for thawing the units in order to maintain a greater amount of cells.

4 Feasibility study thanks to segments in cord blood units

The umbilical cord blood units that are processed have small segments attached to them, with which tests can be done to verify that the respective unit is suitable for transplantation. In this research we can find an example of how the quality of a unit can be verified before being thawed thanks to these segments, taking into account some margins of error that are emphasized.

5 Identification of a genetic variant found in Colombia

Through this research conducted by the IDCBIS Public Cord Blood Bank team, a genetic variant reported for the first time from Colombia was discovered. This discovery is of great importance, since knowing new variants allows to make predictions worldwide about which population could have a higher probability of a donor for certain patients.

6 Study of genes in umbilical cord blood units donated by Colombian mothers

This study reveals gene frequencies in umbilical cord blood units in Colombia that allow us to identify characteristics in our population, with which we can improve the search processes for potential donors; this in order to help patients with serious blood diseases.

In addition to the publications carried out, two new research studies have been submitted for publication: one by the IDCBIS Advanced Therapies Unit to the journal Stem Cells International and another submitted by the IDCBIS Public Cord Blood Bank team to the International Journal of Molecular Sciences.

Comparison of different skin preservation methods with gamma irradiation – Published in Burns in 2017
A new strategy for umbilical cord blood collection developed atthe first Colombian public cord blood bank increases totalnucleated cell content – Published in Transfusion in 2017
Original title: Improved cord blood thawing procedure enhances the reproducibility and correlation between flow cytometry CD34+ cell viability and clonogenicity assays- Published in cytotherapy in 2018.
Cord blood attached-segments are not homogeneous in post-thaw CD34+ cell viability and clonogenicity – Published in Cryobiology in 2018
Identification of the novel HLA-DRB1 allele, DRB1*14:183, in a Colombian umbilical cord blood bank donor – Published in Wiley HLA in 2018
HLA -A,-B,-C and -DQB1 allele and haplotypofrequencies of 1463 umbilical cord blood units typed in high from Bogotá, colombia. – Published in Human Immunology in 2019

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7 out of 10 patients who need a blood-forming cell transplant (bone marrow) do not find a compatible donor in their family, therefore it is necessary to look for this compatibility in unrelated people. Genetic similarity is necessary for the procedure to be successful.

The District Institute of Science, Biotechnology and Innovation in Health IDCBIS, linked to the Health Sector of the Capital District, is carrying out a database of potential donors who could save the lives of patients with diseases such as leukemia, among other serious blood diseases.

The only way to find a compatible, non-family donor is to have previously identified the genetic characteristics of a population and store them in a database, so that the patient's medical team can search for a possible donor. This database is called the National Registry of Hematopoietic Progenitor Cell Donors.

This type of initiative is already being carried out in other countries such as Japan, New Zealand, the United States and more. In Latin America it has been carried out in Mexico, Argentina, Brazil, Chile and Uruguay. For the first time Colombia will have a donor registry.

Since January 21, 2019, the DarCélulas program began, in which the processes of pre-registration and registration to the Registry were organized, as well as the communication to invite people interested in becoming potential donors in this first stage, subsequently when there is an optimal number of donors, the specialists who attend patients who require a transplant will be able to consult the Registry.

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In the online pre-registration stage, through the web page www.idcbis.org.co, Colombians can find out much more about the process, as well as schedule an appointment for registration, then to formalize the registration the interested party attends in person at the IDCBIS District Blood Bank where blood samples will be taken to know their genetic information and to register it in the database that is being built. For now the registration process is only available in Bogota.

The resulting database in all registries at international level is available for searches, therefore there have already been successful cases of transplantation in Colombia, thanks to donors registered in other countries. This initiative in our country would give us the possibility of having Colombian donors, with a greater possibility of being compatible with patients in the same territory, since there is a greater possibility of having similar genetic characteristics.

*On August 22nd at 11:00 a.m. the presenter and journalist, Carlos Calero who is a brand ambassador for DarCélulas will attend the IDCBIS District Blood Bank to register for the program and explain to the public the importance of donating blood-forming cells.

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The twentieth unit of umbilical cord blood cells obtained and processed by the Public Cord Blood Bank IDCBIS was transplanted. A new opportunity for a pediatric patient with a severe blood disease in Bogota. This process was carried out thanks to voluntary and altruistic donations from Colombian mothers since 2014 in the capital.

The Public Cord Blood Bank IDCBIS, linked to the Health Sector of the Capital District, has been in charge of selecting donors, as well as collecting, processing, analyzing, storing, typing and distributing hematopoietic progenitor cells in umbilical cord blood units; which are used for the treatment of different diseases that affect the blood, immune system, metabolism or bone marrow; especially in minor patients.

One of the cases was that of Maryuris, a nine-year-old girl from Barranquilla who recovered from medullary aplasia (a condition in which the bone marrow stops producing hematopoietic progenitor cells totally or partially, affecting the production of blood components), at a major pediatric hospital in Bogotá, thanks to a transplant performed with umbilical cord blood cells in 2017, shortly after a life-threatening diagnosis by the treating medical team.

You may be interested in: Research Team of the Public Cord Blood Bank IDCBIS makes important publication in the Scientific Journal Human Immunology

Maternal umbilical cord blood contains cells capable of producing blood components, these are called hematopoietic progenitor cells, which, when transplanted into a patient with a serious blood disease, can generate new blood components. A process similar to sowing a seed capable of creating new plants.

Once the donated cord blood cells are stored and cryopreserved, the amount of hematopoietic progenitor cells in each unit is identified. Eight out of ten units do not have the necessary amount of cells to be used for transplantation.

Since 2014, IDCBIS has collected more than 9300 cord blood units, of which more than 1600 have been made available for transplantation. 20 units of cord blood cells have been a hope for relatives of patients in pediatric units in the country.

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The investigation team of the Public Cord Blood Bank IDCBIS reveals frequencies of genes of the population of Bogota donors important in the compatibility in transplants of blood-forming cells, this was done through the study titled HLA -A, -B, -C, -DRB1 and –DQB1 allele and haplotype frequencies of 1463 umbilical cord blood units typed in high resolution from Bogotá, Colombia, which will appear in the important scientific journal Human Immunology member of the American Society of Histocompatibility and Immunogenetics.

Dr. Ana María Perdomo led the research team that carried out the study through which the frequencies of the HLA (Human Leukocyte Antigen) genetic variants of 1463 umbilical cord blood units stored for unrelated transplantation (without family relationship) were calculated. This means a representative sample of the HLA genes of Colombian children, which is immunologically determinant for the eventual transplantation of umbilical cord blood units.

With the statistical data presented in the study, possible associations between the different HLA variants can be inferred, which is useful for blood-forming cell donor registries in the world, to predict possible compatibilities with patients who have similar genotypes, including the possibility of finding a donor in our country. When there is compatibility between donors and patients, rejection at the time of receiving a transplant is avoided.

First Colombian population study typed with five DNA characteristics

Through the collection of more than 9,300 cord blood units since 2014, with 1666 made available for transplantation by the IDCBIS Public Cord Blood Bank, it has been possible to identify the HLAs corresponding to the 1463 units.

Typing is the process through which HLA identification is made, which was performed on each umbilical cord blood unit. This is the first study that takes into account five DNA characteristics in the Colombian population in order to obtain relevant information for transplants.

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The study published in the scientific journal Human Immunology allows an approach to the most frequent variants in the genes present in the HLA in the Colombian population. "Knowing more about the genetic characteristics in high resolution of our population, we can contribute to donor search strategies, as well as make transplant processes increase their chances of success in patients who require it," says Dr. Ana Maria Perdomo, IDCBIS researcher.

The Public Cord Blood Bank IDCBIS, linked to the Health Sector of the Capital District, is in charge of selecting donors, as well as collecting, processing, analyzing, storing, typing and distributing umbilical cord blood units, which are used for the treatment of different diseases that affect the blood, immune system, metabolism or bone marrow, especially in underage patients.

Read the article here

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Presentamos el artículo: Manejo de quemaduras faciales de segundo grado con membrana amniótica preservada en glicerol 85% publicado en la revista Cirugía Plástica Ibero-latinoamericana en el volumen 44 número 4, elaborado por el Dr. Jorge Luis Gaviria, Dra. Viviana Gómez y la Dra. Linda Guerrero. Este artículo presenta la experiencia del uso de la membrana amniótica preservada en glicerol como apósito biológico temporal en el tratamiento de quemaduras faciales de segundo grado, superficial y profundo.

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Bogota City Council awarded in 2020 the Order of Merit to IDCBIS for its contributions to organ and tissue donation.

In what circumstances is tissue donated?

IDCBIS investigates potential treatment for the recovery of patients with corneal disorders

Delegation of researchers from Lazio - Italy visits IDCBIS in search of international cooperation.

IDCBIS researchers receive recognition for discovering stem cell properties that could determine transplant success

Inexhaustible, impact blood donors in the city of Bogota

Donate blood when it is needed most

6 IDCBIS publications in indexed journals show important results of research in advanced therapies.

More than 750 people have said yes to the possibility of donating blood-forming cells in Colombia.

First 20 transplants with umbilical cord blood cells donated by Colombian mothers to IDCBIS's Public Cord Blood Bank

You may be interested in: Research Team of the Public Cord Blood Bank IDCBIS makes important publication in the Scientific Journal Human Immunology

Investigation team of the Public Cord Blood Bank IDCBIS publishes an important article in the scientific journal Human Immunology.

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